1986年本科毕业于浙江大学光学仪器工程学系，同年因成绩优异被首批免试推荐为研究生；

1989年研究生毕业于华南师范大学物理系光学专业，获理学硕士学位；同年留校工作并协助刘颂豪院士创建我国交叉学科领域第一个以激光生命科学命名的高科技实验室；1993年首批入选为广东省培养跨世纪人才的“千百十工程”重点培养教师；

1996年晋升并被聘为物理学副教授；1997年被评聘为光学专业硕士生导师�?/p>

1998年应邀赴俄罗斯科学院生物物理研究所短期合作研究�?998年被任命为激光生命科学广东省重点实验室副主任�?/p>

2001年晋升并被优先聘为物理学教授�?002年首批竞聘为华南师范大学光学国家重点学科特聘教授�?003年被评聘为光学专业博士生导师�?004年兼任光子中医学实验室负责人，并协助刘颂豪院士创建我国中医药领域唯一与光学学科交叉的中医药与光子技术重点实验室�?/p>

2005年被任命为省部共建激光生命科学教育部重点实验室副主任�?009年被任命为华南师范大学生物光子学研究院副院长�?/p>

2012年被任命为国家中医药管理局中医药与光子技术三级实验室副主任；

2012年作�?“医用激光技术与仪器”方向学术带头人建设的“光学工程”一级学科获批为广东省重点学科；

2013年负责的“光子中医信息治疗仪器产学研合作基地”被授予广州市建设“广州光谷”的第一批光产业公共服务平台�?/p>

兼任中国光学学会激光医学专业委员会副主任、广东省光学学会副理事长、广东省生物物理学会常务理事、《激光生物学报》常务编委�?/p>

已发表学术论�?00余篇，其中SCI收录60余篇。近三年发表的主要论文（*通讯作者）�?/p>

1)  Zhiming Liu,Zhouyi Guo*,et al,Graphene oxide based surface-enhanced Raman scattering probes for cancer cell imaging;Phys.Chem.Chem.Phys.,2013, 15(8): 2961-2966. (SCI IF3.573)

2)  Zhiming Liu, Shaoxin Li,Zhouyi Guo*,et al, pH-dependent surface-enhanced Raman scattering of aromatic molecules on graphene oxide;J. Raman Spectrosc.2013,44(1), 75-80; (SCI IF3.087)

3)  Xiaochu Qin,Zhouyi Guo*,et al,Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy;J. Photochem.Photobiol. B: Biol.2013,120: 156-162;(SCI IF3.11)

4)  Shao-Xin Li, Qiu-Yao Zeng, Lin-Fang Li, Yan-Jiao Zhang, Ming-Ming Wan, Zhi-Ming Liu, Hong-Lian Xiong,Zhou-Yi Guo*,et al,Study of support vector machine and serum surface enhanced Raman spectroscopy for noninvasive esophageal cancer detection,Journal of Biomedical Optics,2013, 18(2),27008; (SCI IF2.881)

5) Ping Liu, Yan-Yue Huang,Zhou-Yi Guo,et al,.Discrimination of dimethyl sulphoxide diffusion coefficient in the process of optical clearing by confocal micro-Raman spectroscopy.Journal of Biomedical Optics,2013,18(2): 020507; (SCI IF2.881)

6)  Honglian Xiong,Zhouyi Guo,et al, In vivo detection of Hirschsprung's disease by optical coherence tomography in rats.Phys. Med. Biol.2013,58:1549-156(SCI IF2.701)

7) Zhiming Liu, Huiqing Zhong, Juan Zhai, Chuanxing Wang, Honglian Xiong andZhou-Yi Guo*,Acute Skin Lesions following Psoralen Plus Ultraviolet A Radiation Investigated by Optical Coherence Tomography,Laser Physics�?013, 23(8): 085601. (SCI IF2.545)

8) Zhiming Liu, HuiqingZhong,Zhouyi Guo*,et al,Conformation dependentsurface-enhanced Raman scattering of graphene oxide/metal nanoparticle hybrids,Chinese Optics Letter�?013,11(8), 83001-83003.(SCI, IF: 0.968)

9) Mingming Wan, Zhiming Liu, Shaoxin Li, Biwen Yang, Wen Zhang,Xiaochu Qin,Zhouyi Guo*, Silver Nanoaggregates on Chitosan Functionalized Graphene Oxide for High-Performance Surface-Enhanced Raman Scattering,Applied Spectroscopy,2013,67(7),761-766,(SCI IF1.942)

10)  Zhengfei Zhuang, Ning Li,Zhouyi Guo*,et al,Study of molecule variations in renal tumor based on confocal micro-Raman spectroscopy;J. Biomedical Optics2013, 18(3), 031103; (SCI IF2.881)

11)  Zheng-Fei Zhuang, Mei-Fang Zhu,Zhou-Yi Guo*,et al,Second Harmonic Generation in 3-D Uniform Arrangement of Type I Collagen on Nonlinear Optics Microscopy.Scanning�?013,35(1):12-16(SCI IF1.287)

12) Zhengfei Zhuang, Meifang Zhu,Zhouyi Guo*,et al,Study of molecule variation in various grades of human nuclear cataracts by confocal micro-Raman spectroscopy;Appl. Phys. Lett.,2012.101(17): 173701;(SCI IF3.844)

13) Zhiming Liu, Chaofan Hu,Zhouyi Guo*,et al,Rapid intracellular growth of gold nanostructures assisted by functionalized graphene oxide and its application for surface-enhanced Raman spectroscopy;Analytical Chemistry�?012�?4(23)�?0338-44;(SCI IF5.856)

14) Xi Guo;Zhouyi Guo*;et al,Silver-gold core-shell nanoparticles containing methylene blue as SERS labels for probing and imaging of live cells;Microchimica Acta2012, 178, 229-36.;(SCI IF3.033)

15)  N. Li, S.X. Li,Z.Y. Guo,et al,Micro-Raman spectroscopy study of the effect of Mid-Ultraviolet radiation on erythrocyte membrane;J. Photochem.Photobiol. B: Biol.112 (2012) 37�?2;(SCI IF3.11)

16) Shao-Xin Li, Qiu-Yan Chen Yan-Jiao Zhang, Zhi-Ming Liu, Hong-Lian Xiong,Zhouyi Guo*;et al,Detection of nasopharyngeal cancer using confocal Raman spectroscopy and genetic algorithm technique;J. Biomedical Optics2012, 17(12), 125003; (SCI IF3.157)

17) Deqiu Huang; Wen Zhang,Zhouyi Guo*;et al,Optical clearing of porcine skin tissue in vitro studied by Raman microspectroscopy;J. Biomedical Optics2012, 17 (1), 015004;(SCI IF3.157)

18)  Y. R. Ni,Z. Y. Guo*,et al,Determination of Optical Properties of Oxidative Bleaching Human Dental Tissue Samples Using Optical Coherence Tomography; Laser Physics�?012, 22(01)�?94-299; (SCI IF3.605)

19)  P. Liu, J. H. Li, Z. W. Tu,Z. Y. Guo,et al,Discrimination of NPC Cell Lines Associated with Malignant Types Using Raman Spectroscopy;Laser Physics�?012, 22(11)�?-6; (SCI IF3.605)

20)  Wen-Zhuo Yin,Zhou-Yi Guo,et al,Application of surface-enhanced Raman in skin cancer by plasma;Laser Physics�?012, 22(5): 996-1001(SCI IF3.605)

21)  Zheng-Fei Zhuang, Ke Xiong,Zhou-Yi Guo*,et al,Micro-Raman spectroscopy Study of Human Pterygium and Conjunctival Melanocytic Nevi.Scanning�?012,34(6):395-398(SCI IF1.287)

22)  Rui Li,Zhou-Yi Guo,et al,Quantitative analysis of crystal violet by Raman spectroscopy;Spectroscopy�?012,27(3): 54-57.(SCI IF0.50)

23) Wen Zhang,Zhouyi Guo*,et al,Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide;Biomaterials�?011�?2(33)�?555-61;(SCI IF7.882)

24) Chuanxing Wang, Siyun Shu,Zhouyi Guo*et al, Immunohistochemical localization of mu opioid receptor in the marginal division with comparison to patches in the neostriatum of the rat brain,Journal of Biomedical Science�?011�?8(34) ; (SCI IF1.962)

25) Yirong Ni, Siyun Shu,Zhouyi Guo,et al,Dissociated brain organization for two-digit addition and subtraction: An fMRI investigation;Brain Research Bulletin, 2011�?6(5-6):395-402;(SCI IF2.818)

26) Yirong Ni,Zhouyi Guo*,et al,Quantification of color alteration in human teeth with optical coherence tomography;Laser Physics�?011,21 (11):1999-2004; (SCI IF1.319)

27) Yirong Ni,Zhouyi Guo*,et al,The potential optical coherence tomography in tooth bleaching quantitative assessment;Laser Physics�?011,21 (12):2138-2142; (SCI IF1.319)

28) Long Tian, Huajiang Wei, Ying Jin, Hanping Liu,Zhouyi Guo,et al,Backward emission angle of microscopic second-harmonic generation from crystallized type I collagen fiber,J. Biomedical Optics2011, 16 (7),075001;(SCI IF3.157)

29) Huiqing Zhong,Zhouyi Guo,et al,Quantification of glycerol diffusion in human normal and cancer breast tissuesin vitrowith optical coherence tomography;Laser Physics Letters�?010�?(04)�?35-320;(SCI IF5.502)

30) Huiqing Zhong,Zhouyi Guo,et al,Enhancement of permeability of glycerol with ultrasound in human normal and cancer breast tissuesin vitrousing optical coherence tomography;Laser Physics Letters�?010�?(05)�?88-395;(SCI IF5.502)

31) Huiqing Zhong,Zhouyi Guo,et al,In vitro study of ultrasound and glycerol induced changes in human skin optical attenuation assessed with optical coherence tomography,J. Biomed. Opt.. 2010,15(3), 036012.(SCI IF2.501)

32) Huiqing Zhong,Zhouyi Guo,et al,Synergistic Effect of Ultrasound and Thiazone �?PEG 400 on Human Skin Optical Clearingin vivo;Photochemistry and Photobiology,2010, 86: 732�?37;.(SCI IF2.253)

33) Long. Tian, Junle Qu,Zhouyi Guo,et al,Microscopic second-harmonic generation emission direction in fibrillous collagen type I by quasi-phase-matching theory,J. Appl. Phys.2010,108: 054701.(SCI IF2.072)

34) Zhiming Liu,Zhouyi Guo*,et al,Quantitative optical coherence tomography of skin lesions induced by different ultraviolet B sources;Phys. Med. Biol.; 2010, 55: 6175�?185; (SCI IF2.781)

35) Huiqing Zhong,Zude Zhang,Zhouyi Guo*,et al,Using OCT Image to Distinguish Human Acupoint from Non-acupoint Tissues after irradiation with laserin vivo: A Pilot study;Chinese Optics Letter;2010, 8(4), 418-420.(SCI IF0.968)

36)  Zheng-Fei Zhuang, Han-Ping Liu,Zhou-Yi Guo,et al,Second-harmonic generation as a DNA malignancy indicator of prostate glandular epithelial cells;ChinesePhysicsB.;2010,19(4): 049501.(SCI IF1.148)

参与编著�?/span>美国NOVA出版社关于石墨烯的最新专著：�?/span>Graphene Oxide: Synthesis, Mechanical Properties and Applications�?/span>，并负责编写该书的第二章�?/span>Applications of Graphene-Based Nanomaterials in Cancer Research�?/span>�?/span>该章从肿瘤的诊断、成像以及治疗三个方面介绍了氧化石墨烯（GO）这一新型纳米材料在生物医学领域中的潜在应用�?/span>该论著是对本课题组近几年在石墨烯研究领域所取得成果的一次全面总结。在肿瘤诊断方面，利用肿瘤细胞内存在的氧化还原体系合成了GO与纳米金的复合物，该复合物能够作为一种新颖的SERS底物用于肿瘤细胞的快速拉曼检测［Anal. Chem.�?/span>2012�?/span>］；在肿瘤成像方面，设计了一种新型的基于GO�?/span>SERS探针，实现了肿瘤细胞的快�?/span>SERS成像�?/span>Phys. Chem. Chem. Phys.�?/span>2013）］；在肿瘤治疗方面，将GO作为一种既可载热又可载药的纳米平台，实现了肿瘤的光热化疗［Biomaterials�?/span>2011）； J. Photochem. Photobiol. B�?/span>2013�?/span>2014）］。同时，在石墨烯的生物毒性方面，探究了石墨烯衍生材料�?/span>GQDs）的生物相容性［Nanoscale Res. Lett.�?/span>2014）］。另外，课题组还对石墨烯�?/span>SERS活性基底制备以及环保领域等方面的应用也有所建树，相关论文发表在�?/span>J. Raman Spectrosc.�?/span>2013）；Appl. Spectrosc.(2013) �?/span> Appl. Surf. Sci.(2014) �?/span>Chem. Eng. J.(2014) ］等国际权威期刊上�?/span>

（详�?/span>学校新闻链接�?/span> http://news.scnu.edu.cn/?p=809 )

目前主持承担的科研项目：

1、主持承担国�?/em>自然科学基金面上项目：基于光学成像技术的石墨�?金属复合物在肿瘤化疗联合近红外光热疗法中的应用研究（61275187�?

2、主持承担广东省自然科学基金重点项目：适用于光学成像导向的脑肿瘤治疗的多功能石墨烯纳米复合物构建研究（2014A030311024�?/span>

3、主持承担教育部博士学科点专项科研基�?博导�?项目：基于氧化石墨烯纳米载体�?/span>808nm激光联合靶向药物治疗肿瘤的研究�?/span>20114407110001�?

4、主持承担广东省教育厅科技创新项目：脑靶向石墨烯纳米载体的构建及其在神经胶质瘤的化疗联合近红外光热疗中的应用研�?2013KJCX0052)

5、主持承担无限极（中国）有限公司委托重大技术开发项目“微激光若干应用关键技术开发研究�?/span>

(详见学校新闻�?/span>我校郭周义教授团队获重大横向项目资助
链接�?/span>http://www.scnu.edu.cn/scnu/NewsCenter/HSContextfinal.jsp?code=2&tit=23150&column=xykx)

近期参与负责的科研项目：

6、参与负责国家自然科学基金重点项目：经穴效应细胞分子机理的光学表征（61335011�?

7、参与负责广东省重大科技专项项目：基于多普勒OCT的心脑眼血管病变的早期无创预警设备研制(2012A080203008)

8、参与负责广东省教育部产学研结合重点项目：眼科光学断层无损检测仪研制与开发（2011A090200011�?/span>

已经主持完成的主要科研项目：

9、国家自然科学基金面上项目：UV辐射对角质形成细胞DNA的损害及修复作用研究”（60778047�?

10、教育部博士学科点专项科研基�?博导�?项目�?08nm低强度激光经颅照射对SD大鼠脑缺血/再灌注损伤保护作用的研究(200805740003)

11、教育部科学技术研究重点项目：激光与细胞和生物大分子的作用机理研�?02113)

12、广东省自然科学基金重点项目：双氢青蒿素（DHA）诱导肿瘤细胞凋亡的分子机理研究�?251063101000009�?

13、广东省自然科学基金面上项目：激光在穴位照射治疗过程中的针灸手法模拟研究�?6025080�?

14、广东省自然科学基金面上项目：低强度激光诱导软骨缺损修复的效应及其作用机制研究�?31518�?

15、广东省国际合作计划项目：光学相干层析成像技术及其在中医诊断中的应用研究(2005B50101015)

16、广东省重点科技攻关项目：用于调理亚健康态的光子中医信息理疗保健仪器的研�?2008B030303074)

17、广东省重点科技攻关项目：光子中医信息疗法研究及其治疗仪研制与开�?2004B33101006)

18、广东省重点科技攻关项目：荧光法免疫分析技术研究及其测试仪研制(2002C60113)

19、广东省重点科技攻关项目：纺织品防紫外线性能研究及其测试仪研�?2001C10905)