一�?/span>个人简�?/span>

胡祥�?博士、研究员�?span style="background: #FFFFFF; line-height: 150%; font-family: 微软雅黑, Microsoft YaHei;">广东省杰出青年科学基金获得者�?span style="color: #000000; font-family: 微软雅黑, Microsoft YaHei; background-color: #FFFFFF;">“香江学者计划”入选者�?/span>广东省科技创新青年拔尖人才入选者、中科院优秀博士学位论文获得�?/span>。以第一/通讯作者在J. Am. Chem. Soc., Advanced Materials, Chemistry of Materials, Chemical Science, Biomaterials, Macromolecules 等国际著名期刊发表多篇SCI 论文，其中，�?/span>1篇入�?/span>“ESI热点论文�?(学科领域�?.1%论文)�?篇论�?/span>入选“ESI 高被引论文�?(引用次数排在学科领域�?%的论�?�?/span>单篇最高引�?60余次�?/span>发表论文总引�?300余次，H指数�?8�?/span> 研究成果曾被Nature 集团旗下SciBX周刊发文评述，或入选美国化学会志亮点论文，并被JACS Spotlights专栏评论报道等�?/span>

目前主要从事生物功能高分子、聚集诱导发光材料、分子影像和分子探针研究，探索解决肿瘤诊疗、生物成像及病原微生物防治中的科学问题。现主持国家自然科学基金面上项目�?/span>广东省杰出青年科学基金�?/span>国家自然科学青年基金、广东省特支计划科技创新青年拔尖人才项目等�?span style="color: windowtext; line-height: 150%; font-family: 微软雅黑,Microsoft YaHei; font-size: 20px;">另外，指导多名博士生和硕士生开展科研工作，�?位获研究生国家奖学金(硕博�?�?�?位获华南师范大学研究生“十佳学术论文”�?/span>

二�?/span>学习经历

2010/9 - 2014/1 中国科学技术大学，高分子科学与工程系，博士，导师：刘世勇教�?/span>

2007/9 - 2010/7 安徽师范大学，化学与材料科学学院，硕士，导师：罗时忠教授

2003/9 - 2007/7 安徽师范大学，化学与材料科学学院，学士，保研, 指导老师：王绍武教授，晏利琴副教�?/span>

三、工作经�?/span>

2017/01 - 至今 香港科技大学，“香江学者”计划，导师：唐本忠院士 

2017/05 - 至今 华南师范大学，激光生命科学教育部重点实验室，研究�?/span>

2015/12 - 2017/04 华南师范大学，激光生命科学教育部重点实验室，副研究员

2014/7 - 2015/12 华南师范大学，激光生命科学教育部重点实验室，讲师

2014/2 - 2014/7 广东省微生物研究所，华南应用微生物国家重点实验室，助理研究�?/span>

四、学术兼�?/span>

中国生物医学学会生物医学光子学青年委员，中国化学会会员，Advanced Functional Materials, Theranostics, Macromolecules, Chemistry of Materials, Theranostics, Biomacromolecules, Polymer Chemistry, ACS Applied Materials & Interfaces, Biomaterials Science, Chinese Journal of Polymer Science, 高分子学报等期刊审稿人�?/span>

2018

[29] W. H. Wang, G. H. Liang, W. J. Zhang, D. Xing*, X. L. Hu* �?/span>Cascade Promoted Photo-Chemotherapy against Resistant Cancers by Enzyme-Responsive Polyprodrug Nanoplatforms�?Chemistry of Materials, 2018, 30, 3486-3498.

[28] J. Yang, S. D. Zhai, H. Qin, H. Yan, D. Xing*, X. L. Hu* �?/em>NIR-Controlled Morphology Transformation and Pulsatile Drug Delivery Based on Multifunctional Phototheranostic Nanoparticles for Photoacoustic Imaging-guided Photothermal-Chemotherapy�?Biomaterials, 2018, 176, 1-12.

[27] X. L. Hu*, S. D. Zhai, G. H. Liu, D Xing, H. J. Liang, S. Y. Liu* �?/span>Concurrent Drug Unplugging and Permeabilization of Polyprodrug-Gated Crosslinked Vesicles for Cancer Combination Chemotherapy�?Advanced Materials, 2018, 30, 1706307.

[26] D. Wang, H. F. Su, Ryan T. K. Kwok, X. L. Hu*, H. Zou, Q. X. Luo, Michelle M. S. Lee, W. H. Xu, Jacky W. Y. Lam. B. Z. Tang* �?/em>Rational Design of a Water-soluble NIR AIEgen, and its Applications for Ultrafast Wash-free Cellular Imaging and Photodynamic Cancer Cell Ablation�?Chemical Science, 2018, 9, 3685-3693.

[25] D. D. Zhang, L. W. Wen, R. Huang, H. H. Wang, X. L. Hu*, Da Xing* �?/span>Mitochondrial Specific Photodynamic Therapy by Rare-earth Nanoparticles Mediated Near-infrared Graphene Quantum Dots�?Biomaterials, 2018, 153, 14-26.

2017

[24] N. Zhao, B. Y. Wu, X. L. Hu*, Da Xing* �?/span>NIR-triggered High-efficient Photodynamic and Chemo-Cascade Therapy Using Caspase-3 Responsive Functionalized Upconversion Nanoparticles�?Biomaterials, 2017, 141, 40-49.

[23] S. D. Zhai, X. L. Hu*, Y. J. Hu, B. Y. Wu, Da Xing* �?/span>Visible Light-induced Crosslinking and Physiological Stabilization of Diselenide-rich Nanoparticles for Redox-responsive Drug Release and Combination Chemotherapy�?Biomaterials, 2017, 121, 41-54.

[22] X. L. Hu*, S. Y. Liu* �?em>Charge-conversional Polyprodrug Amphiphiles for Intracellular Dual-responsive Drug Delivery�?/span> Journal of Controlled Release, 2017, 259, e144.

[21] T. R. Kuang, L. Q. Chang,* X. F. Peng, X. L. Hu*, D. G. Perez �?/span>Molecular Beacon Nano-Sensors for Probing Living Cancer Cells�?Trends in Biotechnology, 2017, 35(4), 347�?59.

[20] J. Qi, Y. Fang, Ryan T. K. Kwok, X. Y. Zhang, X. L. Hu, Jacky W. Y. Lam, D. Ding*, B. Z. Tang* �?em>Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice�?ACS Nano, 2017, 11(7), 7177-7188.

2016

[19] Z. Q. Yu, B. Yan, L. Q. Gao, C. B. Dong, J. Zhong，M. D. Ortenzio, B. Nguyen, X. L. Hu*, F. Liang* �?/span>Targeted Delivery of Bleomycin: a Comprehensive Anticancer Review�?Current Cancer Drug Targets, 2016, 16, 509-521.

[18] T. R. Kuang, Y. R. Liu, T. T. Gong, X. F. Peng, X. L. Hu*, Z. Q. Yu^* �?/span>Enzyme-Responsive Nanoparticles for Anticancer Drug Delivery�?Current Nanoscience, 2016, 12, 38-46.

2015

[17] X. L. Hu, G. H. Liu, Y. Li, X. R. Wang, S. Y. Liu* "Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Drug Release and Enhanced Magnetic Resonance Signals", Journal of the American Chemical Society, 2015, 137, 362�?68. (Highlighted by JACS Spotlights,�?/span>ESI Highly Cited Papers�?/span>)

[16] X. L. Hu*, Y. Li, T. Liu, G. Y. Zhang*, S. Y. Liu* �?/span>Intracellular Cascade FRET for Temperature Imaging of Living Cells with Polymeric Ratiometric Fluorescent Thermometers�?ACS Applied Materials & Interfaces, 2015, 7, 15551-15560.

[15] X. L. Hu*, S. Y. Liu* �?/span>Recent Advances towards Fabrication and Biomedical Applications of Responsive Polymeric Assemblies and Nanoparticle Hybrid Superstructures�?/span> Dalton Transactions, 2015, 44, 3904-3922. (Perspective Article)

2014

[14] X. L. Hu, Y. Li, T, Liu, G. Y. Zhang, S. Y. Liu* �?em>Photo-Degradable Neutral-Cationic Brush Block Copolymers for Nonviral Gene Delivery�?strong>Chemistry-An Asian Journal, 2014, 9, 2148-2155.

[13] X. L. Hu, Y. Li, T. Liu, G. Y. Zhang, S. Y. Liu* �?/span>Responsive Polymer-Based Multicolor Fluorescent Probes for Temperature and Zn²⁺ Ions in Aqueous Media�?Science China Chemistry, 2014, 57, 615-623.

[12] Y. M. Li, X. L. Hu, S. D. Tian, Y. Li, G. Q. Zhang, G. Y. Zhang*, S. Y. Liu* "Polyion Complex Micellar Nanoparticles for Integrated Fluorometric Detection and Bacteria Inhibition in Aqueous Media", Biomaterials, 2014, 35, 1618-1626.

2013

[11] X. L. Hu, J. M. Hu*, J. Tian, Z. S. Ge, G. Y. Zhang, K. F. Luo, S. Y. Liu* �?em>Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking and Drug Delivery�?Journal of the American Chemical Society, 2013, 135, 17617�?7629. (Highlighted by SciBX, a weekly publication from Nature and BioCentury; “ESI Hot Papers�?�?/span>ESI Highly Cited Papers")

[10] X. L. Hu, J. Tian, T. Liu, S. Y. Liu* �?em>Photo-Triggered Release of Caged Camptothecin Prodrugs from Dually Responsive Shell Cross-Linked Micelles�?Macromolecules, 2013, 46, 6243-6256. (Monthly most-read articles)

[9] X. L. Hu, H. Li, S. Z. Luo*, T. Liu, Y. Y. Jiang, S. Y. Liu* �?em>Thiol and pH Dual-Responsive Dynamic Covalent Shell Cross-Linked Micelles for Triggered Release of Chemotherapeutic Drugs�?Polymer Chemistry, 2013, 4, 695-706. (One of the 2013's Most-Accessed Polymer Chemistry articles, “ESI Highly Cited Papers�?/span>)

2012

[8] T. Liu, Y. F. Qian*, X. L. Hu, Z. S. Ge*, S. Y. Liu* �?a name="OLE_LINK39">Mixed Polymeric Micelles as Multifunctional Scaffold for Combined Magnetic Resonance Imaging Contrast Enhancement and Targeted Chemotherapeutic Drug Delivery�?Journal of Materials Chemistry, 2012, 22, 5020-5030.

[7] T. Liu, X. J. Li, Y. F. Qian*, X. L. Hu, S. Y. Liu* �?em>Multifunctional pH-Disintegrable Micellar Nanoparticles of Asymmetrically Functionalized beta-Cyclodextrin-Based Star Copolymer Covalently Conjugated with Doxorubicin and DOTA-Gd Moieties�?Biomaterials, 2012, 33, 2521-2531.

2011

[6] S. Z. Luo*, X. L. Hu, C. X. Ling, X. Liu, S. S. Chen, M, C, Han. �?em>Multiarm Star-like Unimolecular Micelles with a Dendritic Core and A Dual Thermosensitive Shell�?Polymer International, 2011, 60, 717�?24.

[5] S. Z. Luo*, X. L. Hu, Y. Y. Zhang, C. X. Ling, X. Liu, S. S. Chen. �?em>Synthesis of Thermoresponsive Unimolecular Polymeric Micelles with a Hydrophilic Hyperbranched Poly(glycidol) Core�?Polymer Journal, 2011, 43, 41�?0.

[4] Y. Y. Jiang, X. L. Hu, J. M. Hu, H. Liu, H. Zhong*, S. Y. Liu* �?em>Reactive Fluorescence Turn-On Probes for Fluoride Ions in Purely Aqueous Media Fabricated from Functionalized Responsive Block Copolymers�?Macromolecules, 2011, 44, 8780-8790.

[3] S. Z. Luo*, C. X. Ling, X. L. Hu, X. Liu, S. S. Chen, M, C, Han, J. Xia. �?em>Thermoresponsive Unimolecular Micelles with a Hydrophobic Dendritic Core and a Double Hydrophilic Block Copolymer Shell�?Journal of Colloid and Interface Science, 2011, 353, 76�?2.

[2] J. M. Hu, X. Z. Zhang, D. Wang, X. L. Hu, T. Liu, G. Y. Zhang*, S. Y. Liu* �?em>Ultrasensitive Ratiometric Fluorescent pH and Temperature Probes Constructed from Dye-Labeled Thermoresponsive Double Hydrophilic Block Copolymers�?Journal of Materials Chemistry, 2011, 21, 19030-19038.

[1] X. J. Li, Y. F. Qian, T. Liu*, X. L. Hu, G. Y. Zhang, Y. Z. You, S. Y. Liu* �?em>Amphiphilic Multiarm Star Block Copolymer-Based Multifunctional Unimolecular Micelles for Cancer Targeted Drug Delivery and MR Imaging�?Biomaterials, 2011, 32, 6595-6605.

专利情况

[1] 胡祥�?/span>，邢达，曹冰，一种三氯生两亲性聚合物纳米粒子及其制法与抗菌应用，国家发明专利申请号：ZL 201611080868.2

[2] 胡祥�?/span>，邢达，肖凤峰，一种细菌靶向纳米粒子的制备及其抑杀细菌的应�? 国家发明专利申请号：ZL 201710940630.0

[3] 刘世勇�?strong>胡祥�?/strong>，喜树碱前药单体及其聚合前药两性分子、以及它们的制备和用�?(已授�?�?国家发明专利：ZL 201310438480.5  授权公告日：2015�?�?4日�?/span>

[4] 刘世勇�?strong>胡祥�?/strong>，制备喜树碱聚合前药两性分子的纳米粒子的方法及其产品和用�?已授�?�?国家发明专利：ZL 201310436641.7  授权公告日：2015�?�?2日�?/span>

主持科研项目与人才基�?/span>

[1] 国家自然科学基金面上项目(2017 - 2021)

[2] 广东省杰出青年科学基�?(2016 - 2020)

[3] 广东省特支计划科技创新青年拔尖人才项目 (2016 - 2018)

[4] 国家自然科学基金青年项目 (2015 - 2017)，已结题

[5] 广东省自然科学基金博士启动项�?(2015 - 2017)，已结题

[6] 广州市科学研究专项基�?(2016 - 2017)，已结题

2015�?中国科学院优秀博士学位论文�?/span>

2016�?华南师范大学年度考核优秀个人

19. 2018/05/05-08 中国化学年年会第31届学术年�? 杭州，聚前药策略在诊疗学中的应用，口头报告�?/span>

18. 2018/04/06-09 International Conference on Organic and Polymer Synthesis (ICOPS 2018), Guangzhou, Best Poster Award.

17. 2018/03/24 Hong Kong Scholars Annual Symposium-2018, Hong Kong, A water-soluble NIR AIEgen for ultrafast wash-free cellular imaging and photodynamic cancer cell ablation, Oral Report, Best Oral Presentation.

16. 2017/12/08-10  2017年广东省生物物理年会, 广州从化, 刺激响应性生物功能高分子与杂化材料在疾病诊疗中的应用, 邀请报�?/span>

15. 2017/11/10-13  Asia Communications and Photonics Conference (ACP) 2017, GuangZhou, Stimuli-responsive Biofunctional Polymers and Hybrid Platforms for Disease Theranostics, Invited report

14. 2017/10/10-14  2017年全国高分子学术论文报告会，成都，聚前药两亲分子在肿瘤诊疗与病原微生物防治中的应�?/span>, 口头报告

13. 2017/09/23-25 4th Sino-UK plus Bilateral Symposium on Macromolecules and Soft Matter, Hefei, Biodegradable Polymeric Antimicrobial to Combat the Infection and Drug Resistance of MRSA, poster

12. 2017/06/19-23  9th International Conference on Materials for Advanced Technologies (ICMAT 2017), Singapore, Stimuli-responsive functional Polymers for Tumor Theranostics, oral report

11. 2016/12/07-09  2016年中国药学大�? 北京，光响应“呼吸型纳米粒子”的制备与肿瘤诊疗应用，邀请报�?/strong>

10. 2016/11/25-27 第一届“木棉花开”先瞻高分子学术研讨会，广州，光响应纳米粒子的肿瘤诊疗应用，邀请报�?/strong>

9. 2016/9/23-26  4th Symposium on Innovative Polymers for Controlled Delivery(SIPCD 2016), Suzhou, Charge-conversional polyprodrug amphiphiles for intracellular dual-responsive drug delivery, poster

8. 2016/7/30-8/4 International Nanomedicine Conference, Mauritius, Diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy, poster

7. 2016/1/1-4 中国化学会第30届学术年�? 大连，纳米生物效应与纳米药物化学分会�?strong>口头报告

6. 2015/12/19-20 中国生物医学工程学会生物医学光子学分会成立大会及学术交流大会，武�?/span>

5. 2015/11/19-22 中国生物材料大会, 海口, Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Drug Release and Enhanced Magnetic Resonance Signals, poster

4. 2015/11/17-21 2015全国高分子学术论文报告会，苏州，海报

3. 2015/4/6-9 International Conference on Nanomedicine and NanoBiotechnology (ChinaNanomedicine 2015), Hangzhou, poster

2. 2015/1/8-10 International Symposium on Translational Nanomedicine, Guangzhou, poster

1. 2014/12/5-6  2014年广东生物物理学年会暨第十一届粤港生物物理学研讨�? 广东开平，聚前药两亲分子多级纳米结构微调控与生物效应，口头报告